# nmcli -h
Usage: nmcli [OPTIONS] OBJECT { COMMAND | help }

OBJECT
  g[eneral]       NetworkManager's general status and operations
  n[etworking]    overall networking control
  r[adio]         NetworkManager radio switches
  c[onnection]    NetworkManager's connections
  d[evice]        devices managed by NetworkManager
  a[gent]         NetworkManager secret agent or polkit agent

# man nmcli

       connection - start, stop, and manage network connections

       device - show and manage network interfaces

# systemctl restart NetworkManager
# nmcli networking off && nmcli networking on

# nmcli c reload                <- If you change the configuration file manually

# nmcli c down ens160 && nmcli c up ens160

##Briefly
# nmcli d
# nmcli device

## Detail
# nmcli d show eno1
# nmcli device show eno1

# nmcli connection modify eno1 ipv4.addresses "192.168.0.100/24 192.168.0.1"

# nmcli connection down eno1 && nmcli connection up eno1
# nmcli device show eno1

# nmcli connection modify eno1 ipv4.addresses "192.168.0.100/24"
# nmcli connection modify ens3 ipv4.gateway 192.168.0.1

# nmcli connection down eno1 && nmcli connection up eno1
# nmcli device show eno1

# nmcli connection modify eno1 ipv4.dns "192.168.0.100 192.168.0.101"
# nmcli connection down eno1 && nmcli connection up eno1

How to change about DEFROUTE=no

# nmcli con modify eno1 ipv4.never-default yes
# cat /etc/sysconfig/network-scripts/ifcfg-eno1 |grep DEFROUTE
DEFROUTE=no

How to change about DEFROUTE=yes

# nmcli con modify eno1 ipv4.never-default no
# cat /etc/sysconfig/network-scripts/ifcfg-eno1 |grep DEFROUTE
DEFROUTE=yes

# nmcli connection modify eno1 ipv4.routes "10.0.0.0/24 192.168.0.1"
# nmcli connection down eno1 && nmcli connection up eno1
# nmcli con show eno1   <- check

# nmcli con mod ens0 ipv4.gateway 10.0.0.1
# nmcli connection down ens0 && nmcli connection up ens0
# nmcli con show ens0   <- check

Linux Commands Cheat Sheet